Stroke is the leading cause of disability in the United States. It is estimated that about one-third of stroke patients develop Post-Stroke Depression (PSD)- making it one of the most common complications of stroke. If not screened, patients with PSD are more often undiagnosed and untreated. Untreated PSD leads to a further deterioration in quality of life, which affects recovery of one’s strength and disability after a stroke, makes the individual more prone to death and results in significant caregiver stress. There is a critical need to identify the sub-group of stroke patients at a high risk of developing PSD, and detect and treat PSD. The Wayne State University Comprehensive Stroke Program; comprised of a team of 7 neurologists, critical care specialists, stroke fellows, research nurses and nurse coordinators, is looking to develop a program where PSD can be detected early- at one to three months), and initiate early treatment, thereby improving the chances of a better recovery and an enhanced quality of life. Funds provided by MIRA will help the Comprehensive Stroke Clinic establish a program to address PSD in a systematic and timely manner.